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1

New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-Affinity γ-Hydroxybutyrate (GHB) Binding Sites

Vogensen, Stine B., Marek, Aleš, Bay, Tina, Wellendorph, Petrine, Kehler, Jan, Bundgaard, Christoffer, Frølund, Bente, Pedersen, Martin H. F., Clausen, Rasmus P.

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 415 KB

english, 2013

2

PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia

Kehler, Jan, Nielsen, Jacob

Journal:

Current Pharmaceutical Design

Année:

2011

Langue:

english

Fichier:

PDF, 409 KB

english, 2011

3

The potential therapeutic use of phosphodiesterase 10 inhibitors

Kehler, Jan, Ritzén, Andreas, Greve, Daniel Rodriguez

Journal:

Expert Opinion on Therapeutic Patents

Année:

2007

Langue:

english

Fichier:

PDF, 222 KB

english, 2007

4

Syntheses of Methylphosphinic Acids using Tandem Pudovik/Abramov-Barton/McCombie Reactions

Kehler, Jan, Hansen, Henrik I.

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Année:

1999

Langue:

english

Fichier:

PDF, 69 KB

english, 1999

5

ChemInform Abstract: Syntheses and GABA Receptor Binding Properties of 4-Amino-1-, 2-, and 3-hydroxybutylphosphinic Acids.

Jan Kehler, Bjarke Ebert, Otto Dahl, Povl Krogsgaard-Larsen

Journal:

Année:

1999

Fichier:

PDF, 34 KB

1999

6

ChemInform Abstract: Piperidinyl-3-phosphinic Acids as Novel Uptake Inhibitors of the Neurotransmitter γ-Aminobutyric Acid (GABA).

Jan Kehler, Tine B. Stensboel, Povl Krogsgaard-Larsen

Journal:

Année:

1999

Fichier:

PDF, 34 KB

1999

7

ChemInform Abstract: Chemoselective Synthesis of Dithymidine Phosphorothioate in Solution Using O-Protected Thiophosphate Monomers

Thomas Boesen, Jan Kehler, Otto Dahl

Journal:

Année:

1999

Fichier:

PDF, 24 KB

1999

8

ChemInform Abstract: A Convenient Preparation of Difficultly Accessible sec-Alkylmethylphosphinates Using Sequential Pudovik/Abramov—Barton/McCombie Reactions.

Henrik I. Hansen, Jan Kehler

Journal:

Année:

2000

Fichier:

PDF, 31 KB

2000

9

ChemInform Abstract: Synthesis and Pharmacology of Seleninic Acid Analogues of the Inhibitory Neurotransmitter γ-Aminobutyric Acid.

Nicolai Stuhr-Hansen, Bjarke Ebert, Povl Krogsgaard-Larsen, Jan Kehler

Journal:

Année:

2000

Fichier:

PDF, 30 KB

2000

10

Versatile Synthesis of 3-Arylindan-1-ones by Palladium-Catalyzed Intramolecular Reductive Cyclization of Bromochalcones.

Ask Pueschl, Hans Christian Rudbeck, Andre Faldt, Allesia Confante, Jan Kehler

Journal:

Année:

2005

Fichier:

PDF, 17 KB

2005

11

ChemInform Abstract: Novel, Versatile Three-Step Synthesis of 1,2,3,4,10,10a-Hexahydropyrazino[1,2-a]indoles by Intramolecular Carbene-Mediated C—H Insertion.

Niels Krogsgaard-Larsen, Mikael Begtrup, Matthias M. Herth, Jan Kehler

Journal:

Année:

2011

Fichier:

PDF, 50 KB

2011

12

Discovery of Benzamide Analogues as a Novel Class of 5-HT3 Receptor Agonists

Dr. Charlotte G. Jørgensen, Dr. Bente Frølund, Dr. Jan Kehler, Dr. Anders A. Jensen

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 328 KB

english, 2011

13

New solid phase synthesis of oligodeoxythymidine phosphorodithioates by a modified HObt-method

Anne B. Eldrup, Jakob Felding, Jan Kehler, Otto Dahl

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 226 KB

english, 1995

14

Solid phase synthesis of oligodeoxynucleoside phosphorodithioates by a phosphotriester method using a chemoselective coupling reagent

Jan Kehler, Ask Püschl, Otto Dahl

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 318 KB

english, 1996

15

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: Synthesis and pharmacology at glutamate receptors

Charlotte G. Jørgensen, Hans Bräuner-Osborne, Birgitte Nielsen, Jan Kehler, Rasmus P. Clausen, Povl Krogsgaard-Larsen, Ulf Madsen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 293 KB

english, 2007

16

Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors

Battistina Asproni, Gabriele Murineddu, Amedeo Pau, Gérard A. Pinna, Morten Langgård, Claus Tornby Christoffersen, Jacob Nielsen, Jan Kehler

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 458 KB

english, 2011

17

Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters

Heidi Roggen, Jan Kehler, Tine Bryan Stensbøl, Tore Hansen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 137 KB

english, 2007

18

Identification of a new series of non-peptidic NK3 receptor antagonists

Karsten Juhl, Tore Hansen, Jan Kehler, Nikolay A. Khanzhin, Morten B. Nørgaard, Thomas Ruhland, Dorrit B. Larsen, Klaus G. Jensen, Björn Steiniger-Brach, Søren M. Nielsen, Klaus B. Simonsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2011

19

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors

Jan Kehler, Andreas Ritzen, Morten Langgård, Sebastian Leth Petersen, Mohamed M. Farah, Christoffer Bundgaard, Claus Tornby Christoffersen, Jacob Nielsen, John Paul Kilburn

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2011

20

Syntheses and GABA receptor binding properties of 4-amino-1-, 2-, and 3-hydroxybutylphosphinic acids

Jan Kehler, Bjarke Ebert, Otto Dahl, Povl Krogsgaard-Larsen

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 664 KB

english, 1999

21

Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid

Jan Kehler, Henrik I Hansen, Connie Sanchez

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 96 KB

english, 2000

22

Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABAA receptors

Bjarke Ebert, Martin Mortensen, Sally A. Thompson, Jan Kehler, Keith A. Wafford, Povl Krogsgaard-Larsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 189 KB

english, 2001

23

Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter γ-aminobutyric acid (GABA)

Jan Kehler, Tine B. Stensbøl, Povl Krogsgaard-Larsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 236 KB

english, 1999

24

Synthesis and hybridization properties of an acyclic achiral phosphonate DNA analogue

Jan Kehler, Ulla Henriksen, Helene Vejbjerg, Otto Dahl

Journal:

Bioorganic & Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 151 KB

english, 1998

25

Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C–H insertion

Niels Krogsgaard-Larsen, Mikael Begtrup, Karla Frydenvang, Jan Kehler

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 562 KB

english, 2010

26

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

J?rgensen, Charlotte G., Clausen, Rasmus P., Hansen, Kasper B., Br?uner-Osborne, Hans, Nielsen, Birgitte, Bj?rn Metzler,, Kehler, Jan, Krogsgaard-Larsen, Povl, Madsen, Ulf

Journal:

Organic & Biomolecular Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 303 KB

english, 2007

27

Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: Role played by PLC-γ, IP3 receptors

Kanako Itoh, Tamaki Ishima, Jan Kehler, Kenji Hashimoto

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 756 KB

english, 2011

28

Reduction of shunt obstructions by using a peel-away sheath technique? A multicenter prospective randomized trial

Uwe Kehler, Niels Langer, Jan Gliemroth, Ullrich Meier, Johannes Lemcke, Christian Sprung, Hans-Georg Schlosser, Michael Kiefer, Regina Eymann, Oliver Heese

Journal:

Clinical Neurology and Neurosurgery

Année:

2012

Langue:

english

Fichier:

PDF, 309 KB

english, 2012

29

Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists

Dorte Krehan, Bente Frølund, Povl Krogsgaard-Larsen, Jan Kehler, Graham A.R. Johnston, Mary Chebib

Journal:

Neurochemistry International

Année:

2003

Langue:

english

Fichier:

PDF, 78 KB

english, 2003

30

Synthesis and Biological Evaluation of 4-(Aminomethyl)-1-hydroxypyrazole Analogues of Muscimol as γ-Aminobutyric Acid A Receptor Agonists

Petersen, Jette G., Bergmann, Rikke, Møller, Henriette A., Jørgensen, Charlotte G., Nielsen, Birgitte, Kehler, Jan, Frydenvang, Karla, Kristensen, Jesper, Balle, Thomas, Jensen, Anders A., Kristiansen

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 583 KB

english, 2013

31

Atypical delayed intracranial haematoma following stereotactic biopsy of a right parietal anaplastic oligodendroglioma

Roland Kranz, Jan Gliemroth, Christian Gaebel, Birgit Reincke, Hans Arnold, Uwe Kehler

Journal:

Clinical Neurology and Neurosurgery

Année:

2003

Langue:

english

Fichier:

PDF, 456 KB

english, 2003

32

Cerebral haemodynamic pathologies in HELLP syndrome

U. Knopp, U. Kehler, H. Rickmann, H. Arnold, Jan Gliemroth

Journal:

Clinical Neurology and Neurosurgery

Année:

2003

Langue:

english

Fichier:

PDF, 344 KB

english, 2003

33

Neuroradiological findings in primary cerebral lymphomas of non-AIDS patients

Jan Gliemroth, Uwe Kehler, Christian Gaebel, Hans Arnold, Ulrich Missler

Journal:

Clinical Neurology and Neurosurgery

Année:

2003

Langue:

english

Fichier:

PDF, 384 KB

english, 2003

34

Ring–chain tautomerism and protolytic equilibria of 3-hydroxy-3-phosphonoisobenzofuranone studied by 1H, 13C and 31P NMR-controlled titrations

Augner, Sven, Kehler, Jan, Szakács, Zoltán, Breuer, Eli, Hägele, Gerhard

Journal:

New Journal of Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 299 KB

english, 2008

35

Patented PDE10A inhibitors: novel compounds since 2007

Kehler, Jan, Kilburn, John Paul

Journal:

Expert Opinion on Therapeutic Patents

Année:

2009

Langue:

english

Fichier:

PDF, 783 KB

english, 2009

36

Malignant perivascular melanoma mimicking primary central nervous system vasculitis

Martin Schneider, Jan Höltje, Uwe Kehler, Volker Hartmann…

Journal:

Journal of Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 377 KB

english, 2013

37

N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors

Kilburn, John Paul, Kehler, Jan, Langgård, Morten, Erichsen, Mette N., Leth-Petersen, Sebastian, Larsen, Mogens, Christoffersen, Claus Tornby, Nielsen, Jacob

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 3.22 MB

english, 2013

38

Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1

Jensen, Anders A., Erichsen, Mette N., Nielsen, Christina W., Stensbøl, Tine B., Kehler, Jan, Bunch, Lennart

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 136 KB

english, 2009

39

Correlating the Metabolic Stability of Psychedelic 5-HT2AAgonists with Anecdotal Reports of Human Oral Bioavailability

Leth-Petersen, Sebastian, Bundgaard, Christoffer, Hansen, Martin, Carnerup, Martin A., Kehler, Jan, Kristensen, Jesper Langgaard

Journal:

Neurochemical Research

Année:

2014

Langue:

english

Fichier:

PDF, 610 KB

english, 2014

40

New Palladium-Catalyzed Domino Reaction with Intramolecular Ring Closure of an N -(2-Chloro-3-heteroaryl)arylamide: First Synthesis of Oxazolo[4,5- b ]pyrazines

Demmer, Charles S., Hansen, Jacob C., Kehler, Jan, Bunch, Lennart

Journal:

Advanced Synthesis & Catalysis

Année:

2014

Langue:

english

Fichier:

PDF, 3.86 MB

english, 2014

41

Meningitis or leptomeningeal carcinomatosis: Absolute contraindication for 3rd ventriculostomy?

Kehler, Uwe, Gliemroth, Jan, Amold, Hans

Journal:

Clinical Neurology and Neurosurgery

Année:

1997

Langue:

english

Fichier:

PDF, 160 KB

english, 1997

42

Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT 6 and Dopamine D 2 Receptor Ligands.

Krogsgaard-Larsen, Niels, Jensen, Anders A., Schrøder, Tenna J., Christoffersen, Claus. T., Kehler, Jan

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 252 KB

english, 2014

43

Erratum to: Correlating the Metabolic Stability of Psychedelic 5-HT2AAgonists with Anecdotal Reports of Human Oral Bioavailability

Leth-Petersen, Sebastian, Bundgaard, Christoffer, Hansen, Martin, Carnerup, Martin A., Kehler, Jan, Kristensen, Jesper Langgaard

Journal:

Neurochemical Research

Année:

2014

Langue:

english

Fichier:

PDF, 152 KB

english, 2014

44

Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors

Dore, Antonio, Asproni, Battistina, Scampuddu, Alessia, Pinna, Gerard Aime, Christoffersen, Claus Tornby, Langgård, Morten, Kehler, Jan

Journal:

European Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 996 KB

english, 2014

45

Synthesis and Pharmacology of Seleninic Acid Analogues of the Inhibitory Neurotransmitter γ-Aminobutyric Acid

Stuhr-Hansen, Nicolai, Ebert, Bjarke, Krogsgaard-Larsen, Povl, Kehler, Jan

Journal:

Organic Letters

Année:

2000

Langue:

english

Fichier:

PDF, 46 KB

english, 2000

46

4-Aryl-5-(4-Piperidyl)-3-Isoxazolol GABA A Antagonists: Synthesis, Pharmacology, and Structure−Activity Relationships

Frølund, Bente, Jensen, Lars S., Storustovu, Signe I., Stensbøl, Tine B., Ebert, Bjarke, Kehler, Jan, Krogsgaard-Larsen, Povl, Liljefors, Tommy

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 81 KB

english, 2007

47

Reactions of 3-Chloro-3-(Dimethylphosphono) Isobenzofuranone and its Derivatives

Kehler, Jan, Breuer, Eli

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Année:

1999

Langue:

english

Fichier:

PDF, 73 KB

english, 1999

48

Syntheses of novel piperidin-4-ylphosphinic acid, and piperidin-4-ylphosphonic acid analogues of the inhibitory neurotransmitter 4-aminobutyric acid (GABA)

Kehler, Jan, Ebert, Bjarke, Dahl, Otto, Krogsgaard-Larsen, Povl

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1998

Langue:

english

Fichier:

PDF, 116 KB

english, 1998

49

Unusual solvent-dependent behaviour of hydroxyiminophosphonamidates in the Beckmann reactions: choice between rearrangement or fragmentation to metaphosphonamidate species

Kehler, Jan, Breuer, Eli

Journal:

Chemical Communications

Année:

1997

Langue:

english

Fichier:

PDF, 154 KB

english, 1997

50

Synthesis of Oligodeoxynucleoside Phosphoro-Monothioates and Phosphorodithioates by a Phosphotriester Method

Kehler, Jan, Püschl, Ask, Dahl, Otto

Journal:

Nucleosides and Nucleotides

Année:

1997

Langue:

english

Fichier:

PDF, 209 KB

english, 1997